DDX0490P-100 CD290 / TLR10 antibody

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0.1 mg / $440.00
Delivery Time: 7-10 working days*
(*) valid for US customers only

Quick Overview

Mouse anti Human CD290 / TLR10 25F9

DDX0490P-100

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Product Description for CD290 / TLR10

Mouse anti Human CD290 / TLR10 25F9.
Presentation: Purified
Product is tested for Frozen Sections, Flow Cytometry.

Properties for CD290 / TLR10

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Toll-like receptor 10, UNQ315/PRO358
Presentation Purified
Reactivity Hu
Applications C, F
Clonality Monoclonal
Clone 25F9
Host Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9BXR5
Immunogen:
rhTLR10-transfected eukaryotic cells.
GeneID:
81793
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application DDX0490P-50 / DDX0490P-100 Purified: FACS intracellular, ImmunoHistoChemistry frozen sections. 
DDX0490A490-50 / DDX0490A488-100 Alexa-fluor®488 (on request): FACS intracellular,  ImmunoFluorescence. 
DDX0490A546-50 / DDX0490A546-100 Alexa-fluor®546 (on request): FACS intracellular,  ImmunoFluorescence. 
DDX0490A647-50 / DDX0490A647-100 Alexa-fluor®647(on request): FACS intracellular.

Usage recommendation:

*This monoclonal antibody may be used between 1-10 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before using.
Background The Toll-Like Receptors (TLR) is a family of germline-encoded proteins, composed of C-terminal leucinerich repeats (LRR), and an N-terminal Toll/Interleukin-1 Receptor (TIR) domain (1). In humans, 10 TLRs, sharing high sequence homology, have been identified. TLRs are critical for the detection of pathogenassociated molecular patterns (PAMPs) by the innate immune system. LRR recognize PAMPs, and signal transduction events, initiated by the TIR domain, lead to activation of the transcription factors such as AP-1, IRFs and NFkB, and therefore expression of proinflammatory cytokines and costimulatory molecules. TLR10 mRNA is detected in spleen, tonsils, lymph nodes, bone marrow and PBLs. Human TLR10 is an orphan member of the TLR family. Genomic studies indicate that TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2.
(Akira, S et al, Nat Rev Immunol ,2004 4:499-511 ; Flacher V et al, J.Immunol, 2006,177, 959-67 ; Hasan U et al, J.Immunol, 2005, 174, 2942-50).
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol. 2005 Mar 1;174(5):2942-50. PubMed PMID: 15728506.
General Readings
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Format
Buffer System:
Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl Tris PBS 50% glycerol.
State:
Purified
Specificity
Specificity:
Human TLR10.

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