DDX0361A488-100 CD207 / Langerin antibody

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0.1 mg / $530.00
Delivery Time: 7-10 working days*
(*) valid for US customers only

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Mouse anti Human, Mouse, Porcine, Rat CD207 / Langerin 310F7.02/HD26

DDX0361A488-100

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  • DDX0361A488-100

Product Description for CD207 / Langerin

Mouse anti Human, Mouse, Porcine, Rat CD207 / Langerin 310F7.02/HD26.
Presentation: Alexa Fluor 488
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for CD207 / Langerin

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms C-type lectin domain family 4 member K, CLEC4K, Dendritic Cell Marker
Presentation Alexa Fluor 488
Reactivity Hu, Ms, Por, Rt
Applications F, ICC/IF
Clonality Monoclonal
Clone 310F7.02/HD26
Host Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9UJ71
Immunogen:
mouse Langerin-transfected eukaryotic cells
GeneID:
50489
Application Intracellular Flow cytometry, IF
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Valladeau J, Clair-Moninot V, Dezutter-Dambuyant C, Pin JJ, Kissenpfennig A, Mattéi MG, et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J Immunol. 2002 Jan 15;168(2):782-92. PubMed PMID: 11777972.
  2. Treilleux I, Blay JY, Bendriss-Vermare N, Ray-Coquard I, Bachelot T, Guastalla JP, et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin Cancer Res. 2004 Nov 15;10(22):7466-74. PubMed PMID: 15569976.
  3. Douillard P, Stoitzner P, Tripp CH, Clair-Moninot V, Aït-Yahia S, McLellan AD, et al. Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J Invest Dermatol. 2005 Nov;125(5):983-94. PubMed PMID: 16297200.
  4. Nfon CK, Dawson H, Toka FN, Golde WT. Langerhans cells in porcine skin. Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):236-47. doi: 10.1016/j.vetimm.2008.07.012. Epub 2008 Aug 3. PubMed PMID: 18805593.
  5. Bobr A, Olvera-Gomez I, Igyarto BZ, Haley KM, Hogquist KA, Kaplan DH. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol. 2010 Oct 15;185(8):4724-8. doi: 10.4049/jimmunol.1001802. Epub 2010 Sep 20. PubMed PMID: 20855870. (Free PMC Article available, 4 images available)
  6. de Jong MA, de Witte L, Taylor ME, Geijtenbeek TB. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol. 2010 Aug 1;185(3):1633-41. doi: 10.4049/jimmunol.0904137. Epub 2010 Jun 30. PubMed PMID: 20592277.
  7. Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol. 2013 Jan 1;190(1):27-35. doi: 10.4049/jimmunol.1201082. Epub 2012 Dec 3. PubMed PMID: 23209325.
  8. Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, et al. Age-related changes in expression and function of Toll-like receptors in human skin. Development. 2012 Nov;139(22):4210-9. doi: 10.1242/dev.083477. Epub 2012 Oct 3. PubMed PMID: 23034637. (Free PMC Article available, 4 images available)
  9. Hitzler M, Majdic O, Heine G, Worm M, Ebert G, Luch A, et al. Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS One. 2012;7(10):e46776. doi: 10.1371/journal.pone.0046776. Epub 2012 Oct 9. PubMed PMID: 23056446. (Free PMC Article available, 6 images available)
  10. Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, et al. Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun. 2013 May;81(5):1420-9. doi: 10.1128/IAI.01301-12. Epub 2013 Feb 19. PubMed PMID: 23429540. (Free PMC Article available, 4 images available)
  11. Debeer S, Le Luduec JB, Kaiserlian D, Laurent P, Nicolas JF, Dubois B, et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol. 2013 Jul-Aug;23(4):456-66. doi: 10.1684/ejd.2013.2060. PubMed PMID: 24047577.
  12. Segura E, Valladeau-Guilemond J, Donnadieu MH, Sastre-Garau X, Soumelis V, Amigorena S. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med. 2012 Apr 9;209(4):653-60. doi: 10.1084/jem.20111457. Epub 2012 Mar 19. PubMed PMID: 22430490. (Free PMC Article available, 7 images available)
  13. Gerber AL, Münst A, Schlapbach C, Shafighi M, Kiermeir D, Hüsler R, et al. High expression of FOXP3 in primary melanoma is associated with tumour progression. Br J Dermatol. 2014 Jan;170(1):103-9. doi: 10.1111/bjd.12641. PubMed PMID: 24116716.
General Readings
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Format
Label:
Alexa Fluor 488
Purification:
QMA Hyper D ion exchange chromatography
Buffer System:
PBS 50% glycerol
Specificity
Specificity:
mouse Langerin (intracellular epitope)

Accessory Products

Proteins and/or Positive Controls

Proteins for CD207 / Langerin (5 products)

Catalog No. Species Pres. Purity   Source  

CD207 / Langerin

CD207 / Langerin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

CD207 / Langerin (65-328, His-tag)

CD207 / Langerin Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / $820.00
  OriGene Technologies GmbH

CD207 / Langerin (65-328, His-tag)

CD207 / Langerin Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / $320.00
  OriGene Technologies GmbH

CD207 / Langerin (65-328, His-tag)

CD207 / Langerin Human Purified > 90 % by SDS - PAGE
0.25 mg / $1,070.00
  OriGene Technologies GmbH

CD207 / Langerin (65-328, His-tag)

CD207 / Langerin Human Purified > 90 % by SDS - PAGE
50 µg / $320.00
  OriGene Technologies GmbH

Positive controls for CD207 / Langerin (1 products)

Catalog No. Species Pres. Purity   Source  

CD207 overexpression lysate

CD207 overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.
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