DDX0381P-100 CD206 / MRC1 (Extracell. Dom.) antibody

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0.1 mg / $440.00
Delivery Time: 7-10 working days*
(*) valid for US customers only

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Mouse anti Human, Sheep CD206 / MRC1 118F2.02

Product Description for CD206 / MRC1

Mouse anti Human, Sheep CD206 / MRC1 118F2.02.
Properties: (Extracell. Dom.)
Presentation: Purified
Product is tested for Functional assay, Neutralisation, Immunoprecipitation, Flow Cytometry, Frozen Sections, Western blot / Immunoblot.

Properties for CD206 / MRC1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1
Presentation Purified
Reactivity Hu, Sh
Applications C, F, FN, IP, NEUT, WB
Clonality Monoclonal
Clone 118F2.02
Host Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
P22897
Immunogen:
Human CD34+ (GM+TNF)-derived DC.
GeneID:
4360
Property Extracell. Dom.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application DDX0381P-50 / DDX0381P-100 purified: Surface Flow Cytometry, WB, IHC, IP, internalization, inhibition of antibody binding by mannan, dextran-FITC uptake.
Background The mannose receptor (MR) /CD206 is a 175 kDa C-type lectin of type I membrane molecule, with 8 carbohydrate recognition domains (CRD) belonging to the pattern recognition receptors. It is an endocytic receptor of macrophages and endothelial cell subsets whose natural ligands include both self glycoproteins and microbial glycans. CD206 is predominantly expressed in tissue macrophages, myeloid dendritic cells, liver, skin, lymphoid organ and tumor. In humans, the MMR has been detected in cells located within the dermis, lamina propria, and T cell areas of the tonsil, in inflammatory epidermal DCs of atopic dermatitis patients, and in cells lining venous sinuses in the spleen. CD206 is also expressed by human monocyte-derived DCs. mAb 118F2.02 was obtained after mice immunization with human dendritic cells. It recognizes large proteins (160- 200kDa), and its binding to in vitro-generated DC is inhibited by cell preincubation with mannan, suggesting that 118F2.02 is directed against the macrophage mannose receptor. The uptake of mannosylated proteins (expressed on bacteria and fungi) is important for the biologic function of DC. (Sallusto F. et al., 1995, J. Exp. Med., 182, 389-40; Wollenberg A. et al.,J Invest Dermatol, 2002, 119, 5, 1096-102)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995 Aug 1;182(2):389-400. PubMed PMID: 7629501. (Free PMC Article available)
  2. Wollenberg A, Wagner M, Günther S, Towarowski A, Tuma E, Moderer M, et al. Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol. 2002 Nov;119(5):1096-102. PubMed PMID: 12445198.
General Readings
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Format
Buffer System:
Purified: 100 μg in 200 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200 μl PBS 50% glycerol.
State:
Purified
Specificity
Specificity:
Human mannose receptor (extracellular part).-
Species cross-reactivity: Sheep.

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