DDX0080P-100 CD1a antibody

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0.1 mg / $440.00
Delivery Time: 7-10 working days*
(*) valid for US customers only

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Mouse anti Human CD1a 214A9.01

DDX0080P-100

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Product Description for CD1a

Mouse anti Human CD1a 214A9.01.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Frozen Sections, Flow Cytometry.

Properties for CD1a

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a, T6/Leu-6, hTa1, hTa1 thymocyte antigen
Presentation Purified
Reactivity Hu
Applications C, F, WB
Clonality Monoclonal
Clone 214A9.01
Host Mouse
Isotype IgM
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
P06126
Immunogen:
in vitro derived human DCs (GMCSF + TNFα)
GeneID:
909
Isotype control SM13P
Application Flow Cytometry, IHC cryosection, WB.
Background CD1 family molecules have a homologous structure to MHC class I. They are monomorphic proteins of 50 kDa non-covalently associated with β2-microglobulin. Human CD1a molecules are divided in 2 groups. Group 1 includes CD1a, CD1b, and CD1c, while group 2 consists of the CD1d molecule. CD1a is mainly expressed at the cell-surface and in recycling vesicles. CD1a occurs in Birbeck’s granules of Langerhans cells and plays a role in presentation of non-peptide antigens. CD1a is expressed in vitro on CD34+ generated DCs and on monocyte-derived DCs.
(Burdin N. et al, 1999 ; Curr. Opin. Immunol., 11:326-31 ; Valladeau J. et al, 1999; Immunity, 12:71-81)
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Valladeau J, Duvert-Frances V, Pin JJ, Dezutter-Dambuyant C, Vincent C, Massacrier C, et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol. 1999 Sep;29(9):2695-704. PubMed PMID: 10508244.
  2. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81. PubMed PMID: 10661407.
  3. Poulin LF, Salio M, Griessinger E, Anjos-Afonso F, Craciun L, Chen JL, et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010 Jun 7;207(6):1261-71. doi: 10.1084/jem.20092618. Epub 2010 May 17. PubMed PMID: 20479117. (Free PMC Article available, 6 images available)
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Format
Purification:
QMA Hyper D ion exchange chromatography
Buffer System:
100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
State:
Purified
Specificity
Specificity:
human CD1a (epitope in extracellular domain).

Accessory Products

Proteins and/or Positive Controls

Proteins for CD1a (1 products)

Catalog No. Species Pres. Purity   Source  

CD1a

CD1a Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / $748.00
  OriGene Technologies, Inc.

Positive controls for CD1a (1 products)

Catalog No. Species Pres. Purity   Source  

CD1A overexpression lysate

CD1A overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.
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