discontinued

AP16412PU-N Adenosine receptor A2b (C-term) antibody

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Goat anti Human Adenosine receptor A2b

Product Description for Adenosine receptor A2b

Goat anti Human Adenosine receptor A2b.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections.

Properties for Adenosine receptor A2b

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ADORA2B
Presentation Aff - Purified
Reactivity Hu
Applications E, P
Clonality Polyclonal
Host Goat
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P29275
Immunogen:
Peptide with sequence from the C Terminus of the protein sequence (NP_000667.1).
AA Sequence:
CQADVKSGNGQ
GeneID:
136
Property C-term
Application Peptide ELISA: 1/4000 (Detection Limit).
Western Blot: Preliminary experiments in Human Colon, Lung and Placenta lysates gave no specific signal but low background at antibody concentration up to 1 µg/ml.
Immunohistochemistry on Paraffin Sections: 2-4 µg/ml. In paraffin embedded Human Kidney shows cytoplasm staining in cells of renal tubules.
Background Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response, and the inhibition of protein synthesis. The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R, and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthasis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.
Concentration 0.5 mg/ml
General Readings 1. Bazzichi L, Trincavelli L, Rossi A, De Feo F, Lucacchini A, Bombardieri S, Martini C. A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis. Arthritis Res Ther. 2005;7(2):R189-95. Epub 2004 Dec 10.
PMID: 15743465
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography using the immunizing peptide.
Buffer System:
Tris saline, pH~7.3
Preservatives:
0.02% Sodium Azide
Stabilizers:
0.5% BSA
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This anitbody recognizes Adenosine receptor A2b.
Species:
Human.
Gene ID 136
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Accessory Products

Proteins and/or Positive Controls

Positive controls for Adenosine receptor A2b (1 products)

Catalog No. Species Pres. Purity   Source  

ADORA2B overexpression lysate

ADORA2B overexpression lysate
0.1 mg / $295.00
  OriGene Technologies, Inc.
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